In December 2020, it was announced that the 2020–21 Pro14 season would conclude on 27 March 2021 after 16 rounds, and will be followed by the Pro14 Rainbow Cup, a competition featuring the four former South African Super Rugby sides, the Bulls, Lions, Sharks and Stormers.
[1] In April 2021, Dwayne Peel was announced as the head coach for the 2021–22 season, with Glenn Delaney moving to a Director of Rugby role.
[3] At the end of the season, Gareth Davies, Wyn Jones, Ken Owens and Liam Williams were called up to the British & Irish Lions squad for the 2021 tour to South Africa.
A revised knockout stage commenced with a round of 16 consisting of the top eight teams from each pool.
[7] Pool A[9] (+ in the Apps column denotes substitute appearance, positions listed are the ones they have started a game in during the season) Stats correct as of match played 13 June 2021