The season commenced later than usual on 17 October, being played over a shortened 27-game period due to the Coronavirus pandemic.
Limited attendance was allowed at some grounds with strict conditions under the Scottish Government Tier system, dependent on the club's geographical location.
[25] Brechin City chairman Ken Ferguson resigned from the SPFL board on 9 April and was replaced by Clyde representative Gordon Thomson, as Brechin sat bottom of the League Two table and would potentially be affected by the decision on whether the play-offs should proceed.
[25] Both clubs were also crowned their regional league champions in the 2019–20 season, but the promotion/relegation playoff was cancelled due to the COVID-19 pandemic.
As Brechin City lost the play-off, they were relegated to the Highland League since they were north of 56.4513N latitude (middle of the Tay Road Bridge).