Following Atalanta's draw with Sassuolo on 2 May 2021, Internazionale were confirmed as champions for the first time since the 2009–10 Serie A, ending Juventus' run of nine consecutive titles.
[3][4] On 20 August 2020, Spezia won the play-offs to earn its first promotion to Serie A; they became the 66th team to participate in the Italian top-level league.
A day following the Napoli–Genoa match on 27 September 2020, Genoa announced that fourteen of their players tested positive for COVID-19.
[7] On 3 October, two Napoli players, Piotr Zieliński and Eljif Elmas, tested positive for COVID-19, and after the denial of the authorization to leave Naples by the Local Health Authority (ASL), Napoli blocked their players' departure for the match in Turin against Juventus.
[12] Following a successful appeal by Napoli to the CONI Sports Guarantee Board, these penalties were overturned on 22 December.