[3] On 7 January, while Neil Thompson was in caretaker charge, himself with assistants Lee Bullen and Steve Haslam would be affected with COVID-19, meaning they would miss their FA Cup third round clash with Exeter City.

Academy coach Andy Holdsworth, assisted by Daral Pugh, Nicky Weaver and Tony Strudwick would take charge of the game.

[15] On 13 January, the clubs next two league games against Coventry City and Wycombe Wanderers were suspended following other positive COVID-19 tests.

[20] On 2 April, prior to the game against Watford it was announced manager Darren Moore wouldn't be in the dugout due to a positive COVID-19 test.

[21] On 15 April, after Darren Moore's return to the dugout, he would suffer a setback in his recovery, developing pneumonia as a result of COVID-19.

[22] On 26 April, Owls youngster Will Trueman would win the prestigious LFE Championship Apprentice of the Year award.

[28] On 25 June, Wednesday announced a new long-term partnership with Italian sportswear provider Macron, commencing from 1 July 2021.

[36] The third round draw was made on 30 November, with Premier League and EFL Championship clubs all entering the competition.