The 2020–21 Siena Saints men's basketball team represented Siena College in the 2020–21 NCAA Division I men's basketball season.

The Saints, led by second-year head coach Carmen Maciariello, played their home games at the Alumni Recreation Center in Loudonville, New York as members of the Metro Atlantic Athletic Conference.

1 seed in the MAAC tournament, they were upset in the quarterfinals by No.

1 seed in the MAAC tournament, they defeated No.

However, the semifinals and championship game, and all postseason tournaments, were cancelled amid the COVID-19 pandemic.