The 2020–21 South of Scotland Football League was the 75th season of the South of Scotland Football League, and the 7th season as the sixth tier of the Scottish football pyramid system.
Stranraer reserves continued as the reigning champions due to the previous season being declared null and void.
The start of the league season was delayed until October 2020 because of the COVID-19 pandemic, and games were played behind closed doors due to Scottish Government restrictions.
On 11 January 2021 the league was suspended by the Scottish Football Association due to the escalating pandemic situation.
[1] On 1 April clubs voted to declare the season Null and void.