The 2020–21 Southern Illinois Salukis men's basketball team represented Southern Illinois University Carbondale during the 2020–21 NCAA Division I men's basketball season.

The Salukis were led by second-year head coach Bryan Mullins and played their home games at the Banterra Center (formerly SIU Arena) in Carbondale, Illinois as members of the Missouri Valley Conference.

In as season limited due to the ongoing COVID-19 pandemic, the Salukis finished the season 12–14, 5–13 in MVC play to finish in ninth place.

They defeated Bradley in the first round of the MVC tournament before losing to Loyola in the quarterfinals.

In the MVC tournament, the Salukis were eliminated by No.