In addition to the domestic league, Spezia participated in this season's edition of the Coppa Italia.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Last updated: 23 May 2021 Source: Soccerway Note: Coppa Italia match against Roma originally ended in a 4–2 win.

Source: Serie A The League fixtures were announced on 2 September 2020.