The 2020–21 St. John's Red Storm men's basketball team represented St. John's University during the 2020–21 NCAA Division I men's basketball season.

They are coached by Mike Anderson, in his second year at the school, and play their home games at Carnesecca Arena and Madison Square Garden as members of the Big East Conference.

They lost in the quarterfinals of the Big East tournament to Seton Hall.

The Red Storm finished the season 17–15, 5–13 in Big East play to finish in a tie for eighth place.

9 seed in the Big East tournament, they defeated Georgetown in the first round[1] before having their quarterfinal game against Creighton canceled at halftime due to the ongoing coronavirus pandemic.