The Cardinal, led by thirty-fifth year head coach Tara VanDerveer, played their home games at the Maples Pavilion as members of the Pac-12 Conference.

As a result of Santa Clara County, California health orders, the Cardinal were unable to play in Palo Alto for much of their season, moving home games to Kaiser Permanente Arena in Santa Cruz.

They won the Pac-12 women's tournament by defeating UCLA, earning an automatic bid to the NCAA women's tournament where they defeated Utah Valley and Oklahoma State in the first and second rounds, Missouri State in the Sweet Sixteen, Louisville in the Elite Eight, South Carolina in the Final Four and Arizona in the National Championship Game to win its third NCAA title overall and first since 1992.

Haley Jones was named the Final Four Most Outstanding Player.

[1] Roster Last update: April 5, 2021 [2] ^ Coaches did not release a Week 2 poll