Season's start has been delayed due to the COVID-19 second lockdown in Greece that began in November 2020 and started on 16 January 2021.
The following teams have changed division since the 2019–20 season.
Promoted from Gamma Ethniki Relegated from Super League Promoted to Super League Relegated to Football League Relegated to Gamma Ethniki
The following 12 clubs are competing in the Super League 2 during the 2020–21 season.
The top six teams from Regular season will meet once (5 matches per team) for places in 2021–22 Super League Greece as well as deciding the league champion.