[2] The start of the season was delayed due to the COVID-19 pandemic in Switzerland.
The league held its winter break between 22 December 2020 and 23 January 2021.
2019–20 Swiss Challenge League champions FC Lausanne-Sport and runner-up FC Vaduz were promoted to the 2020–21 Swiss Super League.
They were replaced by Neuchâtel Xamax FCS, who got relegated after finishing last-placed in the 2019–20 Swiss Super League, and FC Thun, who lost the relegation game.
No team was relegated due to the cancellation of the 2019–20 Swiss Promotion League caused by the COVID-19 pandemic in Switzerland.