2020–21 Tottenham Hotspur F.C. Women season

[1] Head coaches Karen Hills and Juan Amoros were relieved of their duties on 19 November with the club sat in 11th place in the league.

[2] Hills had been in charge of the first team since August 2009 while Spurs were playing in the then-third tier South East Combination Women's Football League.

[4] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

[11][12] Due to the delay, the competition only reached the fifth round before the end of the season.

Players listed with no appearances have been in the matchday squad but only as unused substitutes.