The winners earned a berth in the play-off stage of the 2021–22 UEFA Europa League, and also qualified for the 2021 Turkish Super Cup.
The lowest-ranked team to qualify for the next round was Tekirdağspor (ranked 144th).
The highest-ranked team eliminated was Halide Edib Adıvar (ranked 104th).
The lowest-ranked team to qualify for the next round was Tekirdağspor (ranked 144th).
The lowest-ranked team to qualify for the next round was Darıca Gençlerbirliği (ranked 101st).
The highest-ranked team eliminated was MKE Ankaragücü (ranked 18th).
Lowest-ranked team qualifying for the next round was Darıca Gençlerbirliği (ranked 101st).
Highest-ranked team eliminated was Denizlispor (ranked 14th).
The lowest-ranked team to qualify for the next round was Tuzlaspor (ranked 39th).
The lowest-ranked team to qualify for the next round was Konyaspor (ranked 13th).
The highest-ranked team eliminated was Gaziantep FK (ranked 8th).
[25] Source:[5] The final match schedule was announced on 13 April 2021.