The 2020–21 Telenet UCI Cyclo-cross World Cup was a season long cyclo-cross competition, organised by the Union Cycliste Internationale (UCI).

The UCI Cyclo-cross World Cup took place between 4 October 2020 and 24 January 2021.

The top ten finishers received points according to the following table: In comparison to last season, intention was to expand the season from nine to fourteen races.

The calendar included new races in Antwerp, Besançon, Diegem, Dublin, Hulst, Overijse, Villars, Dendermonde and Zonhoven, while the races in Bern, Heusden-Zolder, Iowa and Nommay were dropped.

Due to the COVID-19 pandemic however, the races in Besançon, Diegem, Dublin, Hoogerheide, Duinencross Koksijde, Villars, Waterloo and Zonhoven were cancelled and the cross in Antwerp was dropped from the World Cup and instead integrated into the X²O Badkamers Trophy.