[6][7] On 7 April 2021, the finals were once again relocated, this time to the Krešimir Ćosić Hall in Zadar, after the request of Croatian national health authorities to use the Arena Zagreb.

[12] Teams are ranked according to their UEFA futsal club coefficients, computed based on results of the last three seasons, to decide on the round they enter, as well as their seeding in draws.

[9][13] In early April 2020, UEFA announced that due to the COVID-19 pandemic, the deadline for entering the tournament had been postponed until further notice.

All teams in italics are declared champions or selected to play by the national association following an abandoned season due to the COVID-19 pandemic in Europe, and are subject to approval by UEFA as per the guidelines for entry to European competitions in response to the COVID-19 pandemic.

[16] The schedule of the competition is as follows (all draws are held at the UEFA headquarters in Nyon, Switzerland, unless stated otherwise).

[9] The tournament would have originally started in August 2020, but were initially delayed to October due to the COVID-19 pandemic in Europe.

However, due to the continuing pandemic in Europe, UEFA announced a new format and schedule on 16 September 2020.

The schedule of the competition announced in June 2020, under the original format, was as follows (all draws held at the UEFA headquarters in Nyon, Switzerland, unless stated otherwise).

The eight winners of the round of 16 played in the final tournament, which consisted of the quarter-finals, semi-finals and final (with no third place match unlike previous tournaments), between 28 April and 3 May 2021, at the Krešimir Ćosić Hall in Zadar, Croatia.

[98] The bracket of the final tournament was determined by the seeding, without any draw, as follows (Regulations Articles 14.02, 14.03 and 14.04):[11][99] Times are CEST (UTC+2), as listed by UEFA.