In addition to the domestic league, Sassuolo participated in this season's edition of the Coppa Italia.

The season covered the period from 3 August 2020 to 30 June 2021.

Source: Serie A The league fixtures were announced on 2 September 2020.

[11] The draw for the tournament was held on 8 September 2020.

^ Sassuolo roster divided into two squads.