On 25 April 2021, Dynamo Kyiv won the record-extending 16th title with three matches remaining, after the victory over Inhulets Petrove in the Round 23 home game.

[2] On 7 April 2021 it was announced that most of clubs voted to end competitions a week early on 9 May 2021.

[3][6] This season was the first since the 2015–16, when the league consisted of double round-robin tournament, without the second stage and division to the two groups.

[7] A season, that usually starts in July, was postponed for a month due to the COVID-19 pandemic situation in Ukraine.

[9] At least four managers of the UPL openly expressed their opinion not to postpone any games due to the COVID-19 cases.