Valpo, led by fifth-year head coach Matt Lottich, played their home games at the Athletics–Recreation Center as members of the Missouri Valley Conference.

6 seed in the MVC tournament, they lost to Missouri State in the quarterfinals.

[1] In February 2021, the school officially retired the use of the Crusaders name and mascot due to its use by certain hate groups.

7 seed in the MVC tournament, they defeated Evansville, Loyola–Chicago, and Missouri State[4] to advance to the championship game where they lost to Bradley.

[5] All further postseason play was canceled shortly thereafter due to the ongoing COVID-19 pandemic.