In addition to the domestic league, Villarreal participated in this season's editions of the Copa del Rey and the UEFA Europa League.

On 23 July 2020, the club announced the appointment of three-time Europa League winner and former Spartak Moscow, Sevilla, Valencia, Paris Saint-Germain and Arsenal manager Unai Emery.

[1] On 26 May 2021, Villarreal defeated Manchester United in the UEFA Europa League Final 11–10 on penalties following a 1–1 draw after extra time, winning the competition for the first time in club history.

[2] Win Draw Loss Source: Soccerway Source: La Liga The league fixtures were announced on 31 August 2020.

[39][40] The group stage draw was held on 2 October 2020.