In addition to the domestic league, Vitória de Guimarães participated in this season's editions of the Taça de Portugal and the Taça da Liga.

The season covers the period from 26 July 2020 to 30 June 2021.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Fixtures Source: Soccerway Source: Liga Portugal The league fixtures were announced on 28 August 2020.