The 2020–21 West Virginia Mountaineers women's basketball team represented West Virginia University during the 2020–21 NCAA Division I women's basketball season.

The Mountaineers were coached by twentieth-year head coach Mike Carey, played their home games at WVU Coliseum and were members of the Big 12 Conference.

They received an at-large bid to the NCAA tournament.

As the four seed in the HemisFair Regional they defeated Lehigh before losing to Georgia Tech in the Second Round to end their season.

The Big 12 Tournament, NCAA women's basketball tournament and WNIT were all cancelled before they began due to the COVID-19 pandemic.