The entire season took place against the backdrop of the global COVID-19 pandemic, which necessitated the players' compliance with strict restrictions on contact as well as a lack of fans at all Wolves' home matches until the final day of the campaign.

[1] The team also had to contend with several long-term injuries,[2][3] including the leading goalscorer of the previous seasons, Raúl Jiménez, who suffered a fractured skull during an aerial collision in a 2–1 win at Arsenal on 29 November 2020.

Two days prior to the end of the league season, the club had announced that head coach Nuno Espírito Santo would be leaving by "mutual consent" after the final game following four years at the helm.

Source: Premier League The provisional fixture list was released on 20 August 2020, but was subject to change in the event of matches being selected for television coverage or police concerns.

[11] Note: In group stage matches which were level at the end of 90 minutes, a penalty shoot-out was held, with the winner earning a bonus point.