The 2020–21 Women's EHF Champions League was the 28th edition of Europe's premier club handball tournament, running from 12 September 2020 to 30 May 2021.

Vipers Kristiansand defeated Brest Bretagne Handball to win their first title.

The teams were paired against each other in two-legged home-and-away matches, with the aggregate winners qualifying to the next round.

[2] A total of 21 teams from 15 countries submitted their application for a place in the competition's group stage before the deadline of 10 June 2020.

[3] The final list of 16 participants was revealed by the EHF Executive Committee on 19 June.