The schedule of the competition was as follows (all draws were held at the EHF headquarters in Vienna, Austria).

[3][4][5] The EHF announced that the originally planned first qualification round in September would be skipped.

[6] A total of 24 teams entered the draw for the third qualification round, which was held on Tuesday, 20 October 2020.

In each group, teams played against each other in a double round-robin format, with home and away matches.

The final four was held at the Sala Sporturilor Lascăr Pană in Baia Mare, Romania on 8 and 9 May 2021.