The 2020–21 Wyoming Cowgirls basketball team represented the University of Wyoming in the 2020–21 college basketball season.

The Cowgirls were led by head coach Gerald Mattinson, in his second season.

The Cowgirls played their home games at the Arena-Auditorium and are members of the Mountain West Conference.

The beginning of the season was delayed until at least November 25, as a result of the COVID-19 pandemic.

They defeated Utah State[2] in the Mountain West tournament before losing to Boise State[3] in the semifinals.