The 2020–21 Arkansas State Red Wolves women's basketball team represented Arkansas State University during the 2020–21 NCAA Division I women's basketball season.

The team finished the season with interim head coach and former assistant Destinee Rogers after second-year head coach Matt Daniel resigned on December 13, 2021.

The Red Wolves finished the 2019–20 season 11–19, 8–10 in Sun Belt play, to finish in a tie with Appalachian State for seventh place in the conference.

[2] They made it to the 2020 Sun Belt Conference women's basketball tournament where they were defeated by South Alabama in the first round.

[3] Following the season, all conference tournaments, as well as all postseason play, was cancelled due to the COVID-19 pandemic.