The four clubs qualified for European competition, Omonia, Anorthosis Famagusta, APOEL and Apollon Limassol, received a bye for this round.
Enosis Neon Paralimni received another bye in the draw.
[2] An intermediate round match was played between PAEEK and APOEL on 28 October 2020.
Omonia received a bye to the quarter-finals due to participating in the 2020–21 UEFA Europa League group stage.
The semi-final round draw took place on 22 March 2021[5] and the matches were played on 14–21 April 2021.