The 2020–21 Czech Cup, known as the MOL Cup for sponsorship reasons, was the 28th season of the annual knockout football tournament of the Czech Republic.
The winner of the cup gained the right to play in the third qualifying round of the 2021–22 UEFA Europa League.
The official date for second round matches is 16 September.
[1] Dukla Prague and Hradec Kralové received walkovers to the third round as their scheduled opponents, Aritma Prague and Olympie Březová, decided not to follow the required coronavirus testing protocols.
[2] The match between SK Sigma Olomouc and SK Slavia Prague was postponed due to Slavia Prague's participation in the 2020–21 UEFA Europa League quarter-finals.