Exceptionally, this season the five substitutions were maintained in a maximum of three rounds per team, adopted in May 2020 due to the impact of the COVID-19 pandemic.
[4] Atlético Madrid clinched their eleventh La Liga title on the final matchday of the season, after a 2–1 comeback win against Valladolid.
[5] A total of twenty teams contested the league, including seventeen sides from the 2019–20 season and three promoted from the 2019–20 Segunda División.
The first team to be relegated from La Liga were Espanyol, after a 0–1 loss to city rivals Barcelona on 8 July 2020, ending their 26-year stay in the top tier.
[8] On 12 July 2020, Cádiz became the first side to mathematically be promoted, assured of a return to the top flight after a fourteen-year absence following Oviedo's 4–2 win against Zaragoza.