The 2020–21 season is Leyton Orient's 122nd season in their history and the second consecutive season in EFL League Two, Along with League Two, the club will also participate in the FA Cup, EFL Cup and EFL Trophy.

Source: BBC Win Draw Loss Postponed The 2020–21 season fixtures were released on 21 August.

[29] The draw for both the second and third round were confirmed on September 6, live on Sky Sports by Phil Babb.

[31] The second round draw was made by Matt Murray on 20 November, at St Andrew's.

The list is sorted by squad number when total goals are equal.