[9] On 5 November 2020, Serie B announced it would use VAR from the second half of the season.
DAZN broadcast all matches live domestically, with MyCujoo further distributing games in 15 countries.
The table lists the positions of teams after each week of matches.
In order to preserve chronological evolvements, any postponed matches are not included to the round at which they were originally scheduled, but added to the full round they were played immediately afterwards.
Rules: The relegation play-out was not played because the 16th-placed team Ascoli finished more than 4 points ahead of 17th-placed team Cosenza, then they were relegated directly to Serie C. Cosenza was later readmitted to replace the excluded Chievo.