The race covered 197.2 km (122.5 mi), starting in Leuven and finishing in Overijse.

Originally, the race was to be held on 15 April 2020, but it was postponed due to the COVID-19 pandemic.

[1] With around 11 kilometers to go, on the final ascent of the Moskesstraat, a decisive selection of three riders broke and managed to stay away to contest for the win.

In doing so, Alaphilippe won his first race as world champion after a premature celebration and relegation at the 2020 Liège–Bastogne–Liège a few days prior cost him the win there.

Benoît Cosnefroy of AG2R La Mondiale finished third to complete the podium.