The Bulls were led by sixth-year head coach Lance Leipold and played their home games at the University at Buffalo Stadium as members of the East Division of the Mid-American Conference.

[2] A few days later, the school named Michigan co-defensive coordinator Maurice Linguist the team's new head coach.

Jaret Patterson erupted for 301 yards while scoring 4 touchdowns on 31 carries with fellow Buffalo running back Kevin Marks Jr. and quarterback Kyle Vantrease also recording a rushing touchdown each in Buffalo's 42–17 win in Bowling Green.

[13] The Bulls played their first Saturday game of the season on November 28 against Kent State at UB Stadium.

Patterson's impressive performance against Kent State earned him national attention and calls for him to be added to the watchlist for the Heisman Trophy.

Buffalo defeated Kent State 70–41 and received 56 votes in week 14's AP Poll, coming within striking distance of a national ranking.

Patterson and Marks Jr. each recorded 2 rushing touchdowns each as Buffalo defeated Akron 56–7 and finished the regular season undefeated at 5–0.

Roster Last update: April 24, 2019 Buffalo originally had a game scheduled against Ohio State, but it was canceled due to the COVID-19 pandemic.