The 2021 Davis Cup World Group II knock-out stage will be held on 26–28 November 2021.
The two winners of this round will qualify for the 2022 Davis Cup World Group I Play-offs while the two losers will qualify for the 2022 Davis Cup World Group II Play-offs.
[1] Four teams will play for two spots in the World Group I play-offs, in series decided on a home and away basis.
The two winning teams from the knock-outs will play at the World Group I play-offs and the 2 losing teams will play at the World Group II play-offs.
The draw was held on 22 September 2021.