Novak Djokovic defeated Diego Schwartzman in the final, 7–5, 6–3 to win the men's singles tennis title at the 2020 Italian Open.

Rafael Nadal was the two-time defending champion, but lost to Schwartzman in the quarterfinals.

Casper Ruud became the first Norwegian to reach a Masters 1000 semifinal, surpassing his father Christian Ruud, who reached the quarterfinals of Monte Carlo in 1997.

Click on the seed number of a player to go to their draw section.

The players who also received a bye into the second round were as follows, corresponding each semifinalist from the US Open: The other seven byes were removed and therefore seven players were added into the main draw.