Liga Deportiva Universitaria de Quito's 2020 season was the club's 90th year of existence, the 67th year in professional football, and the 59th in the top level of professional football in Ecuador.

Supplier: Puma[3] Sponsor(s): Banco Pichincha, Discover, GOL TV, Pilsener

Note: Caps and goals are of the national league and are current as of the beginning of the season.

Quito qualified to the 2020 CONMEBOL Libertadores—their 18th participation in the continental tournament—as Runner-up of the 2019 Serie A.

Note: Players in italics left the club mid-season.