In their sixth year under head coach Jim Harbaugh, the Wolverines played only six games (all against conference opponents) in a season shortened by the COVID-19 pandemic, compiling a 2–4 record.

The Big Ten Conference initially canceled the fall sports season, on August 11, 2020,[2] but reversed course on September 16, announcing an eight-game conference-only schedule.

Michigan's final three conference games, against Maryland, Ohio State, and Iowa, were canceled due to COVID-19 outbreaks.

On defense, lineman Kwity Paye led the team in tackles-for-loss and was named second-team all-conference.

[12] On July 9, the Big Ten Conference announced that it would adopt "a conference-only season" for all sports due to the coronavirus pandemic.

[13] On August 11, the Big Ten announced that all fall sports, including football, would be indefinitely postponed due to COVID-19.

The radio announcers are Jim Brandstatter with play-by-play, Dan Dierdorf with color commentary, and Doug Karsch with sideline reports.

On its second play from scrimmage, Minnesota scored via a 14-yard touchdown pass from Tanner Morgan to Ko Kieft.

The Wolverines took the lead when Donovan Jeter recovered a Tanner Morgan fumble and returned it 15-yards for a touchdown.

Michigan extended its lead to 21–10 on an eight-yard touchdown pass from Joe Milton to Ben Mason.

Michigan scored the only points of the fourth quarter via a five-yard touchdown run from Chris Evans.

Michigan State regained the lead in the second quarter on a two-yard touchdown pass from Lombardi to Connor Heyward.

Graduate student kicker Quinn Nordin was successful on his first field-goal attempt of the season for 23 yards in the second quarter.

[35] Indiana opened the scoring in the first quarter via a 13-yard touchdown pass from Michael Penix Jr. to Miles Marshall.

With three successful PATs at Indiana, kicker Quinn Nordin moved into 12th place in all-time scoring for Michigan with 237 points.

[38] Michigan lost to Wisconsin 49–11, their worst loss in Ann Arbor in 85 years, when they dropped a 38-0 decision to Ohio State.

Rutgers added 10 points in the second quarter via a one-yard touchdown run from Langan, and a 38-yard field goal by Valentino Ambrosio.

Michigan finally got on the board later in the quarter via a 46-yard touchdown pass from Cade McNamara to Cornelius Johnson, which made the score 17–7 in favor of Rutgers at half-time.

Michigan added 14 points in the third quarter via a 95-yard kickoff return by Giles Jackson and a nine-yard touchdown pass from McNamara to Nick Eubanks.

Rutgers added 10 points via a 61-yard touchdown pass from Noah Vedral to Bo Melton and a 42-yard field goal by Ambrosio.

In triple overtime, Michigan scored via a one-yard touchdown run from Hassan Haskins.

[48] Penn State opened the scoring in the first quarter via a six-yard touchdown run from Keyvone Lee.