The 2020 Mississippi Valley State Delta Devils football team represented Mississippi Valley State University as a member of the East Division of the Southwestern Athletic Conference (SWAC) during the 2020–21 NCAA Division I FCS football season.

Led by third-year head coach Vincent Dancy, the Delta Devils compiled an overall record of 1–3 with an identical mark conference play, placing last out of fourt teams in the SWAC's East Division.

On July 20, 2020, the Southwestern Athletic Conference announced that it would not play fall sports due to the COVID-19 pandemic, which includes the football program.

[1] The conference is formalizing plans to conduct a competitive schedule for football during the 2021 spring semester.

Due to the SWAC's postponement of the 2020 football season to spring 2021, games against Nicholls, Sam Houston State, and Virginia–Lynchburg were canceled.