They were led by head coach Josh Holliday, in his 8th season at Oklahoma State.

On March 13, the Big 12 Conference canceled the remainder of the season due to the Coronavirus pandemic.

[2] The 2019 Oklahoma State Cowboys baseball team notched a 32–17 (14–9) regular season record and finished third in the Big 12 Conference standings.

Oklahoma State received the Big 12 Conference's automatic bid to the 2019 NCAA Division I baseball tournament and was selected as one of the sixteen Regional hosts (played in Oklahoma City).

The Cowboys defeated Harvard, Nebraska, and Connecticut to win the Oklahoma City Regional but were eliminated from the NCAA tournament by Texas Tech in the Lubbock Super Regional.