The Cowboys played their home games at Boone Pickens Stadium in Stillwater, Oklahoma, and competed in the Big 12 Conference.

In January 2019, head coach Mike Gundy announced the hiring of Kasey Dunn to be the new offensive coordinator, replacing Sean Gleeson, who left to take an assistant coaching position at Rutgers.

[2] The Big 12 media days were held on July 21–22, 2020 in a virtual format due to the COVID-19 pandemic.

The Cowboys will host 3 non-conference games against Oregon State, Tulsa, and Western Illinois.

The Cowboys' scheduled games against Oregon State and Western Illinois were canceled before the start of the 2020 season due to the COVID-19 pandemic.