The Ducks played their home games at Autzen Stadium in Eugene, Oregon, and competed as members of the North Division of the Pac-12 Conference.

[2] However, the decision was reversed on September 24, when the Pac-12 announced that they would play a seven-game schedule starting November 6.

There, they defeated the undefeated South Division champion USC to receive the Pac-12's automatic bid to a New Year's Six bowl game.

In the Pac-12 preseason media poll, Oregon was voted as the favorite to win both the North Division and the Pac-12 Championship Game.

The change occurred after both UCLA and California had their initially scheduled games for Saturday, November 14 (against Utah and Arizona State, respectively), canceled due to COVID-19 outbreaks within the other programs.