[3] On November 21, after losing to Iowa, Penn State's record dropped to 0–5, the worst start in the program's history, dating to 1887.

Started Quarterback Running back Wide receiver Tight end Placekicker Offensive lineman Defensive lineman Punter Linebacker Defensive back Long snappers Source:[7] Because of the ongoing COVID-19 pandemic, Penn State, like other institutions, switched to distance-learning during the spring semester and canceled all sporting events.

Cross-divisional opponents include the Iowa Hawkeyes, Northwestern Wildcats, Nebraska Cornhuskers, and Illinois Fighting Illini.

[9][10] In early August, the 9-game conference schedule increased to 10 games, adding cross-divisional opponent Illinois.

[13][14][15] After the decision to postpone the season, the Big Ten formed a taskforce to investigate options for a return to play.

All other Power Five conferences besides the Pac-12 (which also postponed its season shortly after the Big Ten's decision) were still planning to play in the fall.

[16][17] On September 14, it was reported that the Big Ten was considering the possibility of reversing its decision and playing a shortened conference football season as early as mid-to-late October.

Following their victory over Illinois on December 19, Penn State opted out of a college bowl game appearance.