The 2020 São Paulo Challenger de Tênis is a professional tennis tournament to be played on clay courts.

It is the sixth edition of the tournament which is part of the 2020 ATP Challenger Tour.

It takes place in São Paulo, Brazil between 23 and 29 November 2020.

The following players received wildcards into the singles main draw: The following player received entry into the singles main draw as an alternate: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: