The Horned Frogs competed as a member of the Big 12 Conference and played their home games at Amon G. Carter Stadium on campus in Fort Worth, Texas.

The team was slated to face Arkansas in the Texas Bowl, but had to withdraw due to COVID-19 issues within the program.

Brian Applewhite was hired to fill his role as running backs coach.

The Big 12 media days were held on July 21–22, 2020 in a virtual format due to the COVID-19 pandemic.

The Horned Frogs scheduled games against Cal, Prairie View A&M, were canceled due to the COVID-19 pandemic.