Elizabeth Warren, one of the two current senators from Massachusetts, formed an exploratory committee in December 2018 and declared her intention to run in February 2019.

This remained true in 2020, with Massachusetts being one of six states (along with Hawaii, Vermont, Maryland, California, and New York) to give Biden over 60% of the vote.

[45] Biden swept all demographic groups, garnering 63% of whites, 84% of Latinos, 58% of Catholics, 56% of Protestants, and 86% of Jewish voters.

[44] While Biden overwhelmingly carried Latino voters in the state, Trump improved on his 2016 performance in heavily Hispanic cities such as Lawrence, Chelsea, and Holyoke.

Massachusetts was one of five states in the nation in which Biden's victory margin was larger than 1 million raw votes, the others being California, Maryland, New York and Illinois.