The 2020 West Texas A&M Buffaloes football team represented West Texas A&M University during the 2020–21 NCAA Division II football season as a member of the Lone Star Conference (LSC).

The Buffaloes were led by fourth-year head coach Hunter Hughes and played their home games at Buffalo Stadium in Canyon, Texas.

[2] The Buffaloes were one of the few LSC teams to play in fall 2020 instead of spring 2021.

Due to the COVID-19 pandemic, the Lone Star Conference announced that there would be no in-conference competition.

[5] The Buffaloes' 2020 schedule officially consisted of all non-conference games, with the games against fellow LSC member Angelo State being considered non-conference matches.