FC Köln and the club's third consecutive season in the top flight of German football.

FC Köln participated in this season's edition of the DFB-Pokal.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Source: Soccerway Source: DFB The league fixtures were announced on 25 June 2021.