FSV Mainz 05 and the club's 13th consecutive season in the top flight of German football.

In addition to the domestic league, Mainz participated in this season's edition of the DFB-Pokal.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Win Draw Loss Fixtures Source: Soccerway Source: DFB The league fixtures were announced on 25 June 2021.