It began on 23 July 2021 and concluded on 15 May 2022.
[1] The fixtures were announced on 25 June 2021.
[2] The relegation play-offs took place on 20 and 24 May 2022.
[1][43] All times Central European Summer Time (UTC+2) 1.
FC Kaiserslautern won 2–0 on aggregate